“MedImmune is dedicated to conducting ground-breaking research on the prevention of respiratory syncytial virus (RSV) and influenza in children,” said Alexander A. Zukiwski, M.D., executive vice president and chief medical officer. “We believe the data being presented at the conference may help advance innovative healthcare solutions for these important causes of respiratory infections in children.”

MedImmune abstracts to be presented at IDSA on RSV include:

• Prophylaxis Utilizing Nebulized Motavizumab, a Monoclonal Antibody Against Fusion Protein of Respiratory Syncytial Virus (RSV) Zhang J, et al. Poster Session: October 30, 2009; 12:30 – 2:00 PM; Poster Hall A / Poster # 608

BACKGROUND: Respiratory syncytial virus (RSV) infection is the primary cause of pneumonia and bronchiolitis in young children, and also causes disease in older adults. This study evaluated the prophylactic use of nebulized motavizumab, an investigational anti-RSV humanized monoclonal antibody against RSV fusion protein, in cotton rats. The findings suggest that prophylaxis with nebulized motavizumab may inhibit RSV infection and spread in the lungs and may provide an alternative to the current intramuscular antibody delivery.

MedImmune abstracts to be presented at IDSA on influenza include:

• A Postmarketing Evaluation of the Frequency of Use and Safety of Live Attenuated Influenza Vaccine Use in Unapproved Children Less Than 59 Months of Age Tennis P, et al. Poster Session: October 31, 2009; 12:30-2:00 PM; Hall A / Poster #1179

BACKGROUND: In September 2007, the approval of live attenuated influenza vaccine (LAIV) was expanded for use in children between 24 and 59 months in age. The vaccine was not approved for use in children younger than 24 months, or for use in children with asthma or recurrent wheezing, or those with altered immunocompetence. This study evaluates the usage and safety of the vaccine in those patient populations younger than 59 months of age that were not in the approved indication. The study found that healthcare providers appear to be complying with the indications for the use of LAIV in children <5 years, and no adverse safety outcomes were detected in the small number of children in unapproved groups who received the vaccine.

• Whole Genome Transcriptional Analysis of the Early Immune Responses Induced by Live Attenuated and Inactivated Influenza Vaccines in Young Children Zhu W, et al. Poster Session: October 31, 2009; 12:30-2:00 PM; Hall A / Poster #1181

BACKGROUND: This study examined the early genomic immune response to live attenuated and inactivated vaccines in previously unvaccinated children 12 to 35 months of age. Among LAIV recipients, an increase in interferon (a natural anti-viral immune protein) production was seen, which may partly explain previous clinical study observations of LAIV-induced protection against illness in the first 2 weeks after administration.

• Influenza-Associated Antibiotic Use in Children Receiving Live Attenuated Influenza Vaccine Compared With Inactivated Influenza Vaccine Belshe R, et al. Poster Session: October 31, 2009; 12:30-2:00 PM; Hall A / Poster #1180

BACKGROUND: Influenza illness in children commonly results in the unnecessary use of prescription antibiotics. This analysis evaluated the efficacy of live attenuated influenza vaccine (LAIV) and trivalent inactivated influenza vaccine (TIV) in preventing antibiotic use in children ranging from six months to 17 years in age. Overall, there was less influenza-associated antibiotic use in LAIV recipients due to a lower rate of culture-confirmed influenza with LAIV.

###

Additional information about the 2009 IDSA conference can be found at http://www.idsociety.org/IDSA2009.htm.

About FluMist®

FluMist® (Influenza Vaccine Live, Intranasal) is a vaccine indicated for active immunization of individuals two to 49 years of age against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine.

FluMist is contraindicated in individuals with history of hypersensitivity to eggs, egg proteins, gentamicin, gelatin or arginine or with life- threatening reactions to previous influenza vaccinations, and in children and adolescents receiving concomitant aspirin or aspirin-containing therapy.

Do not administer FluMist to children less than two years of age due to an increased risk of hospitalization and wheezing that was observed in clinical trials. FluMist should not be administered to any individual with asthma and to children less than five years of age with recurrent wheezing unless the potential benefit outweighs the potential risk. Do not administer FluMist to individuals with severe asthma or active wheezing.

If Guillain-Barre syndrome has occurred with prior influenza vaccination or if an individual is immunocompromised, the decision to give FluMist should be based on careful consideration of the potential benefits and risks. FluMist should not be administered to individuals with underlying medical conditions predisposing them to wild-type influenza infection complications unless the potential benefit outweighs the potential risk. FluMist should be given to a pregnant woman only if clearly needed.

Most common adverse reactions (occurring in 10 percent or more of individuals receiving FluMist and at a rate at least five percent higher than in those receiving placebo) are runny nose or nasal congestion in recipients of all ages, fever more than 100 degrees F in children two to six years of age, and sore throat in adults.

FluMist may not protect all individuals receiving the vaccine. FluMist is for intranasal administration only.

Please see complete Prescribing Information for FluMist, call 1-877-FLUMIST (1-877-358-6478) or visit http://www.medimmune.com/pdf/products/flumist_pi.pdf for additional information.

About MedImmune, Inc.

MedImmune, the worldwide biologics business for AstraZeneca PLC (LSE: AZN.L, NYSE: AZN), has approximately 3,100 employees worldwide and is headquartered in Gaithersburg, Maryland. With an advancing pipeline of promising candidates, MedImmune aims to be the next revolutionary force in biotechnology by delivering life-changing products, industry-leading performance, and a tireless commitment to improving patient health. For more information, visit MedImmune’s website at www.medimmune.com.

GAITHERSBURG, Md., June 29 /PRNewswire/ — MedImmune today announced the expansion of the MedImmune Assistance Program for Synagis(R) (palivizumab) designed to provide the antibody at no cost to qualifying patients who lack health insurance and whose family household income falls within a certain range of the Federal Poverty Level (FPL) guidelines established by the U.S. Department of Health and Human Services (HHS). Synagis is a biologic medicine known as a monoclonal antibody administered monthly to high-risk infants to prevent serious lower respiratory tract infection caused by respiratory syncytial virus (RSV), a leading cause of viral respiratory infection among infants.

Effective July 1, 2009, patients with household income up to 400 percent of the FPL (e.g. a household of four with an income up to $88,200), and without healthcare coverage or medical insurance, may be eligible to receive Synagis at no cost. This marks a significant expansion over the program’s previous eligibility ceiling of 250 percent of the FPL (e.g. $55,125 for that same four-member household).

“MedImmune recognizes the rising cost of healthcare and the burden those expenses can have on working families who lack insurance through no fault of their own,” said Tony Zook, MedImmune President. “This expansion of the MedImmune Assistance Program makes it possible for as many as 75 percent of U.S. households without health insurance and with eligible infants to apply to receive the established preventive benefits of Synagis as prescribed by their doctor at no cost to the family.”

The MedImmune Assistance Program is administered as part of the Synagis Reimbursement Hotline and can be reached by calling 1-877-778-9010. A health care provider can review the patient’s eligibility with a program specialist.

In addition, MedImmune supports The Patient Access Network Foundation (PANF), which is an independent, non-profit 501(c)(3) organization dedicated to supporting the needs of insured patients who cannot afford the treatments they need due to out-of-pocket health care costs. More information about the help that’s available for RSV prevention and treatment can be found by visiting www.patientaccessnetwork.org.

About Synagis

Synagis(R) (palivizumab) is a prescription medication that is used to help prevent a serious lung disease caused by respiratory syncytial virus (RSV) in children at high risk. Synagis is given as a shot, usually in the thigh muscle, each month during the RSV season. Children who develop an RSV infection while receiving Synagis should continue the monthly dosing schedule throughout the season.

Synagis should not be used in patients with a history of a severe allergic reaction to Synagis or its ingredients. Cases of severe allergic reactions such as anaphylaxis and other types of hypersensitivity reactions have been reported with Synagis. These reactions may occur when any dose of Synagis is given, not just the first one. Very low platelet counts may occur, which may lead to unusual bruising and/or groups of pinpoint red spots found on the skin.

Common side effects may include fever, cold-like symptoms (upper respiratory infection) including runny nose and ear infection, and rash. Other possible side effects include skin reactions around the area where the shot was given (like redness, swelling, warmth or discomfort). In children born with certain types of heart disease, other possible side effects include bluish color of the skin, lips or under fingernails and abnormal heart rhythms. These are not all the possible side effects of Synagis.

About RSV

Each year, up to 125,000 infants in the United States are hospitalized with severe RSV infections, the leading cause of lower respiratory tract infections in U.S. infants. RSV is the most common respiratory infection in infancy or childhood. Approximately one-half of all infants are infected with RSV during the first year of life, and nearly all children have been infected at least once by the time they reach their second birthday. Children born prematurely as well as those with chronic lung disease (CLD) or congenital heart disease (CHD) are at highest risk for severe disease and hospitalization due to RSV. The virus may also cause severe illness in other high-risk groups.

A recent study published in the New England Journal of Medicine found that RSV accounts for one of every 13 visits to a pediatrician, one of every 38 emergency room trips, and inpatient hospital stays for one out of every 334 children.

About MedImmune

MedImmune, the worldwide biologics business for AstraZeneca PLC (LSE: AZN.L, NYSE: AZN), has approximately 3,100 employees worldwide and is headquartered in Gaithersburg, Maryland. With an advancing pipeline of promising candidates, we aim to be the next revolutionary force in biotechnology by delivering life-changing products, industry-leading performance, and a tireless commitment to improving patient health. For more information, visit MedImmune’s website at www.medimmune.com.

SOURCE: MedImmune 06/29/2009

CONTACT: Tor Constantino of MedImmune, +1-301-398-5801,
constantinos@medimmune.com
Web Site: http://www.medimmune.com
(AZN)

Cancer research has long been a core area of focus at MedImmune and we are proud to share data from our increasingly broad oncology portfolio at this year’s meeting, said Bahija Jallal, Ph.D., senior vice president, research. MedImmune research scheduled to be presented includes:

• Identification of a human antibody 3.19.3 that inhibits ANG-2 function leading to significant anti-tumor activity in a panel of tumor xenograft models (Poster Session: Tumor Biology 1, abstract 137, poster section 5, board 23 ) — Sunday, April 19 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.
• Anti-tumor efficacy of the 3.19.3 ANG-2 antibody in combination with VEGF inhibitors in tumor xenograft models (Poster Session: Tumor Biology 1, abstract 127, poster section 5, board 5) —Sunday, April 19 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.
• Novel antibodies to erbB2 which inhibit the growth of tumor cell lines expressing varying levels of receptor (Poster Session: Experimental and Molecular Therapeutics 2, abstract 831, poster section 36, board 36) — Sunday, April 19 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.
• A fully human antibody that inhibits the integrin avb6 reduces tumor growth and modulates key biomarkers (Poster Session: Experimental and Molecular Therapeutics 2, abstract 847, poster section 36, board 36) — Sunday, April 19 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.
• Inhibition of VEGFR2 dimerisation, a novel mechanism of inhibiting VEGFR2 signaling (Oral Presentation: Tumor Biology 16, abstract 1997) —Monday, April 20 9:30 a.m. — 1:00 p.m. Room 402 — 404, Colorado Convention Center.
• MEDI3617, a fully human anti-angiopoietin 2 monoclonal antibody, demonstrates inhibition and tolerability alone and in combination with chemotherapy in xenograft models (Poster Session: Experimental and Molecular Therapeutics 14, abstract 2793, poster section 32, board 23) — Monday, April 20 from 1:00 p.m. — 5:00 p.m. in Exhibit Hall B-F.
• Isolation of novel functional anticancer antibodies by phage display. (Poster Session: Experimental and Molecular Therapeutics 17, abstract 2876, poster section 35, board 20) — Monday, April 20 from 1:00 p.m. — 5:00 p.m. in Exhibit Hall B-F.
• MEDI-573: A fully human antibody to IGF-I and IGF-II for the treatment of solid tumor and hematological diseases (Poster Session: Experimental and Molecular Therapeutics 15, abstract 2802, poster section 33, board 2) — Monday, April 20 from 1:00 p.m. — 5:00 p.m. in Exhibit Hall B-F.
• In vivo pharmacology of MEDI-573, an anti-IGF-I and IGF-II antibody that targets the IGF-1R and IR-A signaling pathways (Poster Session: Experimental and Molecular Therapeutics 15, abstract 2803, poster section 33, board 3) — Monday, April 20 from 1:00 p.m. — 5:00 p.m. in Exhibit Hall B-F.
• In vitro pharmacological comparison of a CEA/CD3 bispecific cynomolgus-reactive biosimilar BiTE antibody (cyS111) with the clinical candidate MEDI-565 (MT111). (Poster Session: Immunology 5, abstract 3247, poster section 12, board 15) — Tuesday, April 21 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.
• EphB4 inhibits HUVEC cell growth through suppression of the Ras/MAPK pathway. (Poster Session: Cellular and Molecular Biology 54, abstract 4383, poster section 23, board 10) — Tuesday, April 21 from 1:00 p.m. — 5:00 p.m. in Exhibit Hall B-F.
• A fully human antibody inhibits urokinase receptor function in vitro. (Poster Session: Tumor Biology 27, abstract 3091, poster section 6, board 4) — Tuesday, April 21 from 8:00 a.m. — 12:00 p.m. in Exhibit Hall B-F.

About MedImmune
MedImmune, the worldwide biologics business for AstraZeneca PLC (LSE: AZN.L, NYSE: AZN), has approximately 3,100 employees worldwide and is headquartered in Gaithersburg, Maryland. With an advancing pipeline of promising candidates, we aim to be the next revolutionary force in biotechnology by delivering life-changing products, industry-leading performance, and a tireless commitment to improving patient health. For more information, visit MedImmune’s website at www.medimmune.com.

Contacts:
Media: Sidoney Atsé, 301-398-5990

http://www.medimmune.com

“Asthma can be a very debilitating disease, and despite current therapies, patients are in need of novel treatment options,” said Nestor Molfino, M.D., vice president, clinical development, pulmonary disease. “Some asthmatics may show an increased circulation of eosinophils in blood — a certain type of white blood cell believed to play a critical role in the severity and disease pathway of asthma; therefore administration of this antibody may increase asthma control.”

MEDI-563, which was generated using BioWa’s POTELLIGENT(TM) Technology platform, has previously been investigated in a Phase 1 open-label dose-escalating study to evaluate the safety and tolerability of a single intravenous infusion in adults with mild-to-moderate asthma. Data from the completed Phase 1 study demonstrated that the antibody was well-tolerated with biologic activity producing substantial and prolonged depletion of blood eosinophils, thus supporting its continued development. Published literature suggests that reduction of eosinophils in sputum was associated with better asthma control and increases in sputum eosinophilia were associated with exacerbations of asthma. The antibody is also currently being evaluated in a double-blind, placebo-controlled Phase 1 study to evaluate the safety and tolerability and effects of the antibody on airway eosinophils in adults with asthma.

About Interleukin-5 Receptor (IL-5R)

Interleukin-5 is a cytokine secreted predominantly by T-lymphocytes, mast cells, and eosinophils involved in regulating the differentiation, proliferation, and activation of eosinophils via the IL-5 receptor, known as IL-5R. The IL-5R consists of an alpha chain and a beta chain. Expression of the IL-5R alpha chain is restricted largely to eosinophils, basophils, and some mast cells in humans. The alpha-chain exclusively binds IL-5 and the intracellular portion of IL-5Ralpha is involved in cellular activation. Thus, the IL-5R alpha.chain may be a good target for a therapeutic antibody in the management of asthma. Eosinophils, and perhaps basophils and some mast cells, can be preferentially targeted for antibody-dependent cell cytotoxicity through IL-5R alpha chain depleting cells thought to be key in disease pathogenesis and severity. In addition, blocking of IL-5R alpha could provide benefit by neutralizing effects of IL-5.

MedImmune’s Clinical Development in Asthma

MedImmune has multiple approaches in development targeting asthma. Currently, in human testing, the company has antibodies targeting IL-9 and IL-13, in addition to the anti-IL-5R that is the subject of this press release.

About Asthma

Asthma is a chronic disease of the airways that may cause wheezing, breathlessness, chest tightness and coughing. According to the U.S. Centers for Disease Control and Prevention, more than 30 million Americans reported having a history of asthma in 2003, including nine million children. About 20 million said they currently had asthma. In 2000, the CDC reported that there were more than 10 million asthma-related outpatient visits to private physician offices and hospital clinics. The National Institutes of Health have estimated asthma-related healthcare costs in the U.S. at $14 billion annually.

About MedImmune

MedImmune is a leading, innovation-focused biotechnology company whose mission it is to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/ gastrointestinal disease and neuroscience. Headquartered in Gaithersburg, Maryland, MedImmune has approximately 3,000 employees worldwide and is the wholly owned biologics business for AstraZeneca PLC (LSE: AZN.L, NYSE: AZN). For more information, visit MedImmune’s website at http://www.medimmune.com.

SOURCE MedImmune

CONTACT: Media, Sidoney Atse, +1-301-398-5990, or Investors, Peter Vozzo, +1-301-398-4358, both of MedImmune

AstraZeneca today announced that MedImmune, its wholly owned biologics business, has received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) asking for additional information on motavizumab. The CRL is in connection with the Biologics License Application (BLA) for motavizumab for the prevention of serious respiratory syncytial virus (RSV) disease, which was submitted on 30 January 2008. Motavizumab is an investigational monoclonal antibody (MAb).

MedImmune is confident that it can respond to the outstanding questions and, based on the company’s current understanding, does not foresee a need to conduct further trials. MedImmune will continue discussions with the FDA reviewers and, subject to this dialogue, currently expects to resubmit in the first half of 2009.

An update to AstraZeneca investors on progress will be provided when appropriate.

About AstraZeneca
AstraZeneca is a major international healthcare business engaged in research, development, manufacturing and marketing of prescription pharmaceuticals and supplier for healthcare services. AstraZeneca is one of the world’s leading pharmaceutical companies with healthcare sales of US $29.55 billion and is a leader in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infection product sales. AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index. For more information about AstraZeneca, visit www.astrazeneca.com

About MedImmune
MedImmune is a leading innovation-focused biotechnology company whose mission is to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/ gastrointestinal disease and neuroscience. Headquartered in Gaithersburg, Maryland, MedImmune has approximately 3,000 employees worldwide and is the wholly owned biologics business for AstraZeneca PLC. For more information, visit MedImmune’s website at www.medimmune.com.

Media Enquiries:
Neil McCrae +44 207 304 5045 (24 hours)
Sarah Lindgreen +44 207 304 5033 (24 hours)
Chris Sampson +44 20 7304 5130 (24 hours)

Investor Enquiries UK:
Jonathan Hunt +44 207 304 5087 mob: +44 7775 704032
Mina Blair +44 20 7304 5084 mob: +44 7718 581021
Karl Hard +44 207 304 5322 mob: +44 7789 654364

Investor Enquiries US:
Ed Seage +1 302 886 4065 mob: +1 302 373 1361
Jorgen Winroth +1 212 579 0506 mob: +1 917 612 4043
Peter Vozzo (MedImmune) +1 301 398 4358 mob: +1 301 252 7518

28 November 2008

- Ends -

“MedImmune is committed to conducting innovative infectious disease research to determine how best to prevent serious illness that can negatively impact pediatric health, especially during this time of year,” said Alexander A. Zukiwski, M.D., executive vice president and chief medical officer. “We believe the data being presented at this meeting will help lead to important new healthcare solutions, and our company is proud to advance our already robust research base to identify the best ways to help protect children.”

MedImmune abstracts to be presented at ICAAC/IDSA on RSV include:

• Respiratory Syncytial Virus Therapy Utilizing Intranasally Delivered Motavizumab, a Monoclonal Antibody Against the Viral Fusion Protein (#V-4145) B. Richter, Tuesday, October 28, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: A primary cause of pneumonia and bronchiolitis in young children is RSV infection. This preclinical study examined the therapeutic effect of topically administered motavizumab.

• Therapeutic Addition of Motavizumab, a Monoclonal Antibody Against Respiratory Syncytial Virus, Modulates Epithelial Cell Responses to RSV Infection (#V-4146) S. Krishnan, Tuesday, October 28, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: RSV infection of epithelial cells leads to inflammatory host responses. This preclinical study tested whether motavizumab, a humanized monoclonal antibody against the RSV fusion (F) protein, could modulate epithelial cell immune responses to RSV. Lower and upper airway epithelial cells were infected with RSV and motavizumab or a control antibody was subsequently administered at various points post-infection to evaluate the therapeutic addition.

• Total Healthcare Costs of Preterm Infants with Medically Attended Respiratory Syncytial Virus Lower Respiratory Infection (#K-1429 ) D. Stewart, Sunday, October 26, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: While RSV lower respiratory infection (LRI) is the most common cause of hospitalization among infants under one year of age, the total healthcare costs of medically attended RSV LRI for babies of this age group is unknown. This retrospective, propensity-matched cohort assessment sought to determine first-year healthcare costs by examining premature infants born over a five-year period who were insured by a national U.S. health plan, including a subgroup analysis of babies born between 33 and 36 weeks gestation.

• In Vitro Mechanism of Action Studies of the RSV-Neutralizing Monoclonal Antibodies Palivizumab and Motavizumab (#V-4146) K. Huang, Tuesday, October 28, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: Synagis is the only licensed drug product available to help prevent lower respiratory tract RSV infection in premature infants, a leading cause of hospitalizations in this patient population. An affinity-optimized version of Synagis, motavizumab, has been subsequently developed. Since both Synagis and motavizumab bind the RSV fusion (F) protein, which plays a role in virus attachment and mediates the process of virus-cell fusion and cell-to-cell fusion, this study aimed to determine exactly how the drugs neutralize RSV. Four assays were used, which target four distinct steps during virus replication, to identify the mechanism.

• In Vitro and In Vivo Characterization of a Motavizumab-Resistant RSV A Mutant (#V-4148) F. J. Palmer-Hill, Tuesday, October 28, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: This study investigated the growth characteristics – both in vitro and in vivo – of an RSV mutant that was created in the laboratory and is resistant to neutralization by motavizumab, an affinity-optimized MAb directed against the RSV fusion (F) protein. The F protein of the MAb differs from a wild type RSV F protein, so comparisons were made.

• Characterization of Respiratory Syncytial Virus (RSV)Mutants Resistant to Antibody Neutralization with Novel Amino Acid Changes in the RSV Fusion Protein (#V-4149) N. K. Patel, Tuesday, October 28, 2008, Hall C from 12:15 PM to 1:15 PM

BACKGROUND: Synagis is a MAb approved for the prevention of serious lower respiratory tract RSV infection in premature infants. Motavizumab was developed by affinity optimization of Synagis and is characterized by greater in vitro and in vivo neutralization activity against RSV. Previously, the selection of RSV mutants resistant to Synagis has been reported, characterized by amino acid changes in the RSV fusion (F) protein. This study sought to identify the selection and characterization of additional Synagis MAb-resistant mutants, as well as a novel motavizumab MAb-resistant mutant.

MedImmune abstracts to be presented at ICAAC/IDSA on influenza include:

• Influenza-like Illness and Employee Productivity – Results from the Child and Household Influenza-illness and Employee Function (CHIEF) (#K-4207) M. D. Rousculp, Tuesday, October 28, Room 150B from 2:450 PM to 3:00 PM

BACKGROUND: This prospective cohort study of nearly 2,293 U.S. households evaluated the effect of employee and household member influenza-like illness on worker productivity. The households studied were employees from three large Fortune 500 companies. All households included in the study had at least one child. Households were surveyed monthly throughout the 2007-2008 influenza season to determine the impact of influenza-like illness on employees’ work absenteeism and decreased productivity while on the job.

• Impact of Early and Late Influenza Vaccine Availability on In-Office Vaccination Opportunities (#G1-1208) R. Judelsohn, Sunday October 26, Hall C from 11:15 AM to 12:15 PM

BACKGROUND: The CDC now recommends all children from six months to 18 years of age receive an annual influenza vaccination; however, a key barrier to implementation is the inconvenience to parents and providers around scheduling additional office visits to administer the vaccination. This study examined how many more vaccination opportunities exist if influenza vaccination availability were expanded beyond the typical October-to-December timeframe.

• Benefits Versus Risks of Live Attenuated Influenza Vaccine (LAIV) in Young Children (#G1-1204) G. Oster, Sunday October 26, Hall C from 11:15 AM to 12:15 PM

BACKGROUND: In September 2007, approved use of LAIV in the U.S. was expanded to include children aged 24-59 months but with warning/precautions against use in younger children and children 24-59 months with a history of recurrent wheezing or asthma. Since some latter children may receive LAIV in clinical practice, its risks and benefits versus trivalent influenza vaccine (TIV) in this setting must be considered.

Additional information about the 2008 ICAAC/IDSA conference can be found at http://www.icaacidsa2008.org/.

About Synagis
Synagis(R) (palivizumab) is indicated for the prevention of serious lung infections caused by respiratory syncytial virus (RSV) in children at high risk of RSV disease. Synagis is given as a shot, usually in the thigh muscle, each month during the RSV season. The first dose of Synagis should be given before RSV season begins. Children who develop an RSV infection while receiving Synagis should continue the monthly dosing schedule throughout the season. Synagis has been used in more than one million children in the U.S. since its introduction in 1998.

Synagis should not be used in patients with a history of severe prior reaction to Synagis or its components. Cases of severe allergic reactions such as anaphylaxis and other types of hypersensitivity reactions have been reported with Synagis. These reactions may occur when any dose of Synagis is given, not just the first one. Another serious side effect, which may lead to unusual bruising and/or groups of pinpoint red spots found on the skin, has been reported.

Most common side effects with Synagis may include upper respiratory tract infection, ear infection, fever, and runny nose. In children born with heart problems, Synagis was associated with reports of low blood oxygen levels and abnormal heart rhythms. Side effects, such as, skin reactions around the area where the shot was given (like redness, swelling, warmth, or discomfort) have also been reported.

Please see accompanying full prescribing information at http://www.synagis.com.

About FluMist
FluMist(R) (Influenza Virus Vaccine Live, Intranasal) is a live attenuated influenza virus vaccine indicated for active immunization of individuals two to 49 years of age against influenza disease caused by influenza virus subtypes A and type B contained in the vaccine.

FluMist is contraindicated in individuals with history of hypersensitivity to eggs, egg proteins, gentamicin, gelatin or arginine or with life- threatening reactions to previous influenza vaccinations, and in children and adolescents receiving concomitant aspirin or aspirin-containing therapy.

Do not administer FluMist to children less than two years of age due to an increased risk of hospitalization and wheezing that was observed in clinical trials. FluMist should not be administered to any individual with asthma and to children less than five years of age with recurrent wheezing unless the potential benefit outweighs the potential risk. Do not administer FluMist to individuals with severe asthma or active wheezing.

If Guillain-Barre syndrome has occurred with prior influenza vaccination or if an individual is immunocompromised, the decision to give FluMist should be based on careful consideration of the potential benefits and risks. FluMist should not be administered to individuals with underlying medical conditions predisposing them to wild-type influenza infection complications unless the potential benefit outweighs the potential risk. FluMist should be given to a pregnant woman only if clearly needed.

Most common adverse reactions (occurring in 10 percent or more of individuals receiving FluMist and at a rate at least five percent higher than in those receiving placebo) are runny nose or nasal congestion in recipients of all ages, fever more than 100 degrees F in children two to six years of age, and sore throat in adults.

FluMist may not protect all individuals receiving the vaccine. FluMist is for intranasal administration only.

Please see complete Prescribing Information for FluMist, call 1-877-FLUMIST (1-877-358-6478) or visit http://www.flumist.com/prescribing-information.aspx for additional information.

About MedImmune
MedImmune is a leading innovation-focused biotechnology company whose mission is to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/ gastrointestinal disease and neuroscience. Headquartered in Gaithersburg, Maryland, MedImmune has approximately 3,000 employees worldwide and is the wholly owned biologics business for AstraZeneca plc (LSE: AZN.L, NYSE: AZN). For more information, visit MedImmune’s website at http://www.medimmune.com.

Contacts:
Media: Tor Constantino, 301-398-5801
Investors: Peter Vozzo, 301-398-4358
http://www.medimmune.com

“MedImmune is working on a number of potential solutions for patients struggling with systemic autoimmune rheumatic diseases,” said Barbara White, M.D., vice president, clinical development, respiratory, inflammation, and autoimmunity. “We are pleased to share promising basic research and translational science data relevant to the development of new treatments for diseases such as lupus, rheumatoid arthritis, and myositis”

MedImmune programs that will be discussed include:

 -- MEDI-545 - MEDI-545 is a monoclonal antibody (MAb) targeting interferon-alpha, which regulates processes involved in autoimmune diseases. MedImmune has launched a broad development program with this molecule to assess its potential to treat or prevent a variety of immunological disorders. Currently, MedImmune is conducting a phase 2a trial in patients with systemic lupus erythematosus (SLE) and a phase 1b study in patients with active dermatomyositis and polymyositis. The company has also conducted clinical trials in psoriasis with MEDI-545. -- CAM-3001 - CAM-3001 is a MAb with potential to help patients with rheumatoid arthritis. The antibody targets the alpha sub-unit of the granulocyte-macrophage colony stimulating factor receptor (GM-CSFR). CAM-3001 is a phase 1 clinical stage program. -- ICOS - ICOS (Inducible costimulator) is a receptor on activated T-cells that plays a central role in humoral immunity. Elevated levels of ICOS are present in patients with autoimmune diseases and effector cytokines have been shown to correlate with increased levels of this protein. MedImmune has a preclinical program studying the over-expression of ICOS in several autoimmune diseases. -- CXCL13 - CXCL13 is a molecule that recruits B cells into inflammatory cell aggregates called follicles. In patients with rheumatoid arthritis the levels of CXCL13 are elevated within the inflamed joints thus encouraging B cells to accumulate and interact with a range of cells, such as T cells, within the joint promoting the generation of new inflammatory follicles and contributing to the disease process. 

MedImmune has a preclinical program investigating antibodies that target CXCL13 which may have the potential to prevent the generation of these inflammatory follicles within the rheumatic joint.

The schedule for MedImmune’s eight research posters to be presented at the meeting, starting on Sunday October 26, is as follows:

 -- ICOS as a potential regulator in inclusion body myositis and dermatomyositis - Chris Morehouse, M.Sc., Sunday, October 26 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 46 

 -- Internalization of the antibody (CAM-3001) following monocyte cell surface binding to the GM-CSFR alpha chain - Brandon Higgs, Ph.D., Sunday, October 26 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 35 

 -- Neutralization of CXCL13 impacts B-cell trafficking and reduces severity of established experimental arthritis - Matthew Sleeman, Ph.D., Monday, October 27 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 771 

 -- IFN-alpha/beta as a therapeutic target in systemic lupus erythematosus, myositis, and rheumatoid arthritis: a transcript profiling analysis of whole blood from multiple autoimmune diseases - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1346 

 -- Neutralizing IFN-alpha in SLE affects GMCSF, TNF-alpha, IL-10, IL1-beta and BAFF signaling pathways - Brandon Higgs, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1340 

 -- Memory T lymphocytes expressing the inducible costimulator (icos) are required to maintain the secondary lymphoid tissue architecture in non human primates - Gianluca Carlesso, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1843 

 -- In vitro properties of CAM-3001, a human anti GM-CSF receptor antibody for the treatment of patients with rheumatoid arthritis - Matthew Sleeman, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1338 

 -- Use of a SOCS3 ex-vivopharmacodynamic quantitative RT-PCR assay for CAM-3001, a new antibody therapy for the treatment of rheumatoid arthritis - Jo Woods, Ph.D., Tuesday, October 28 from 9:00 a.m. - 11:00 a.m. in Hall A, Abstract: 1339 

About MedImmune

MedImmune is a leading innovation-focused biotechnology company whose mission is to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/ gastrointestinal disease and neuroscience. Headquartered in Gaithersburg, Maryland, MedImmune has approximately 3,000 employees worldwide and is the wholly owned biologics business for AstraZeneca plc (LSE: AZN.L, NYSE: AZN). For more information, visit MedImmune’s website at www.medimmune.com.

SOURCE MedImmune

Boston, MA, October 11, 2008 — MedImmune announced today it will present four abstracts at the American Academy of Pediatrics (AAP) 2008 National Conference & Exhibition that add to the company’s growing body of research into the prevention of respiratory syncytial virus (RSV), a leading cause of viral respiratory infection among preterm infants.

As we gain data that further demonstrate the burden of RSV disease on preterm babies, the benefits of preventive care become more evident, said Jessie R. Groothius, M.D., vice president, medical and scientific affairs, infectious disease. We look forward to presenting studies that demonstrate the importance of better identifying and helping to protect preterm infants from of RSV.

MedImmune abstracts to be presented at AAP include:

• Increased Burden from Late-Preterm Births During the First Year of Life — Kimmie K. McLaurin, MS, Saturday, October 11, 2008, from 10:20 – 10:30 a.m.
  
  BACKGROUND: Recent studies suggest that late-preterm infants (between 33 and 35 weeks gestation) are associated with higher medical costs and greater morbidity than full-term infants during and shortly after birth. The effects of late-preterm births beyond this period, however, are unknown. This retrospective cohort study examined the use of medical resources by late-preterm and full-term infants through their first year of life to determine whether differences in medical costs exist.





• A Multi-Center Prospective Study of the Occurrence and Burden of RSV-Associated Illness in the Emergency Department: September-October 2006 and 2007(Poster #927) — Aleta B. Bonner, MD, Friday, October 10, 2008, from 2:45 p.m.
  
  BACKGROUND: According to the Centers for Disease Control and Prevention, RSV activity is considered widespread in a community when greater than 10-percent of all specimens tested by antigen detection for RSV are positive. Traditionally, widespread activity has been defined as occurring between November and March, yet there is growing evidence that RSV outbreaks vary by geographic region and from year to year. This prospective, multi-center surveillance study examined data recorded in the high-volume outpatient setting of hospital emergency departments (in contrast to hospital inpatient data typically used to demonstrate the burden of RSV-associated illness) to analyze RSV activity in September and October over two consecutive years.





• Identifying Residual Risk of Severe RSV Disease Among Unprophylaxed Preterm Infants (Poster #36) Doris Makari, MD, Friday, October 10, 2008, from 6:00 – 6:30 p.m.
  
  BACKGROUND: The majority of preterm infants are born between 32 and 35 weeks gestation; RSV prophylaxis with Synagis® (palivizumab) has resulted in significant reductions in RSV-associated hospitalizations (RSVH) among this population. The use of Synagis has been restricted, however, due to cost concerns associated with prophylaxis. This retrospective cohort study examined whether risk factors outside of current AAP Red Book guidelines – young chronological age, smoking and overcrowding – could identify a subset population of infants born between 32 and 35 weeks gestation that may be at high risk for RSVH, but not currently recommended for prophylaxis under the AAP guidelines.





• Cost Implications of Expanding Risk Factors for RSV Prophylaxis with Palivizumab for Infants 32-35 Weeks Gestation (Poster #29) — Leonard Krilov, MD, Friday, October 10, 2008 from 6:00 – 6:30 p.m.
  
  BACKGROUND: AAP Red Book guidelines recommend RSV prophylaxis with Synagis for infants born between 32 and 35 weeks gestation with two or more of five risk factors: school-aged siblings, childcare attendance, severe neuromuscular disease, congenital airway abnormality, and exposure to environmental air pollutants (except smoking). Adding select risk factors may help identify a new subset of infants between 32 and 35 weeks gestation at high risk for RSV hospitalization, yet the impact on cost to include those risk factors is not clear. This study examined the cost implications of increasing current risk factor criteria.

Additional information about the 2008 AAP National Conference & Exhibition can be found at http://www.aap.org/nce/.

About RSV
Each year, up to 125,000 infants in the U.S. are hospitalized with severe RSV infections, the leading cause of lower respiratory tract infections in infants in the United States. RSV is the most common respiratory infection in infancy or childhood. Approximately one-half of all infants are infected with RSV during the first year of life, and nearly all children have been infected at least once by the time they reach their second birthday. Children born prematurely as well as those with chronic lung disease (CLD) or congenital heart disease (CHD) are at highest risk for severe disease and hospitalization due to RSV. The virus may also cause severe illness in other high-risk groups such as the elderly, those with underlying respiratory or cardiac disease, and those with compromised immune systems (e.g., bone marrow transplant patients).

About Synagis® (palivizumab)
Synagis is the only monoclonal antibody approved by the FDA to help prevent an infectious disease. Synagis is indicated for the prevention of serious lower respiratory tract disease caused by RSV in children at high risk of RSV disease.

Synagis was approved for use in the United States in 1998, Europe in 1999, and Japan in 2002. Synagis is currently available in 62 countries.

The safety and efficacy of Synagis were established in infants with bronchopulmonary dysplasia, infants with a history of prematurity (less than or equal to 35 weeks gestational age), and children with hemodynamically significant congenital heart disease. The first dose of Synagis should be administered prior to commencement of the RSV season, which usually starts in the fall and runs through the spring. Synagis is administered by intramuscular injection. Patients, including those who develop an RSV infection, should continue to receive monthly doses throughout the season. Abbott has exclusive rights to Synagis in markets outside the United States. MedImmune promotes Synagis in the United States.

Important Safety Information
Synagis® (palivizumab) is indicated for the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus (RSV) in pediatric patients at high risk of RSV disease and is administered by intramuscular injection. Safety and efficacy were established in infants with bronchopulmonary dysplasia (BPD), infants with a history of premature birth (≤35 weeks gestational age), and children with hemodynamically significant congenital heart disease (CHD). Synagis has been used in more than one million children in the U.S. since its introduction in 1998. The first dose of Synagis should be administered prior to commencement of the RSV season. Patients, including those who develop an RSV infection, should continue to receive monthly doses throughout the season.

Synagis should not be used in pediatric patients with a history of severe prior reaction to Synagis or its components. Cases of anaphylaxis were reported following re-exposure to Synagis and severe acute hypersensitivity reactions have also been reported on initial exposure or re-exposure. If a severe hypersensitivity reaction occurs, therapy with Synagis should be permanently discontinued. If milder hypersensitivity reactions occur, caution should be used on re-administration of Synagis. In post-marketing reports, cases of severe thrombocytopenia (platelet count <50,000/microliter) have been reported.

In clinical trials, the most common adverse events occurring at least 1% more frequently in Synagis-treated patients than controls were upper respiratory infection, otitis media, fever, and rhinitis. Cyanosis and arrhythmia were seen in children with CHD. There have also been post-marketing reports of injection site reactions. For full prescribing information for Synagis, see the company’s website at: www.medimmune.com/products/synagis/index.asp.

About MedImmune
MedImmune is a leading innovation-focused biotechnology company whose mission it is to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/ gastrointestinal disease and neuroscience. Headquartered in Gaithersburg, Maryland, MedImmune has approximately 3,000 employees worldwide and is the wholly owned biologics business for AstraZeneca plc (LSE: AZN.L, NYSE: AZN) . For more information, visit MedImmune’s website at www.medimmune.com.

Contacts:
Media: Tor Constantino, 301-398-5801
Investors: Peter Vozzo, 301-398-4358
http://www.medimmune.com

“Lupus can be a debilitating disease that damages organs, causes pain and loss of function, and reduces the quality of life in patients suffering from the disease, who are often young women,” said Barbara White, vice president, clinical development, inflammatory disease. “The Phase 1 trials with this antibody have demonstrated that it can inhibit activity of interferon-alpha in patients with lupus and that its safety profile supports further clinical development in lupus.”

The Phase 2A clinical trial is designed to evaluate the safety and tolerability of multiple subcutaneous dose schedules of MEDI-545 or placebo in adult patients with moderately to severely active lupus. The study will also assess the effects of MEDI-545 on disease activity in lupus patients. This randomized, double-blind, placebo-controlled, parallel-dose trial will be conducted at about 20 sites throughout the United States.

MEDI-545 was generated using the Medarex, Inc. Ultimab Human Antibody Development System(R).

About Lupus

Lupus is an autoimmune disease that can affect various parts of the body, including the skin, joints, heart, lungs, blood, kidneys and brain. Lupus affects approximately 322,000 to possibly over a million people in the United States. Lupus may occur at any age in men or women, but the disease predominantly affects women of childbearing years. The disease has a higher incidence in African-Americans, Hispanics, Asian and American Indians. Treatments for lupus include nonsteroidal anti-inflammatory drugs, corticosteroids, antimalarials, and immunosuppressants.

About MedImmune

MedImmune is wholly owned by AstraZeneca plc (LSE: AZN.L, NYSE: AZN) and is the worldwide biologics business for the AstraZeneca Group. The company has approximately 3,000 employees worldwide and is headquartered in Gaithersburg, Maryland. MedImmune strives to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and

inflammation, cardiovascular/gastrointestinal disease and neuroscience. For more information, visit MedImmune’s website at http://www.medimmune.com.

SOURCE MedImmune

CONTACT: Media: Sidoney Atse, +1-301-398-5990, or Investors: Peter Vozzo, +1-301-398-4358, both of MedImmune

“This phase 2 clinical trial in ALL is an important step to assess activity of blinatumomab in aggressive forms of B cell malignancies and will help to determine the full therapeutic potential of this highly specific and potent BiTE antibody in human B cell cancers,” said Carsten Reinhardt, M.D., senior vice president and chief medical officer of Micromet.

ALL is a very aggressive form of B cell leukemia. Patients with ALL are initially treated with complex and highly toxic chemotherapy regimens, which may be followed by bone marrow stem cell transplantation for eligible patients. Patients who have a low number of residual tumor cells in their bone marrow after chemotherapy (also known as “minimal residual disease” or MRD) are at a very high risk of early relapse. This phase 2 clinical trial recruits patients with MRD and will test whether blinatumomab can eliminate residual tumor cells and prolong the time to relapse. A systematic process has been established for the MRD screening of all ALL patients which are referred to the German ALL study group (GMALL). The patients identified in this screening as MRD-positive are now referred to the clinical trial.

“Improved treatments and reduction of relapse rate in patients with MRD-positive ALL represent a high medical need. Although CD19 is widely expressed in ALL, no therapies targeting CD19 are currently available,” said Professor D. Hoelzer, chairman of the German ALL study group (GMALL).

About BiTE Antibodies

BiTE(R) antibodies are designed to direct the body’s cytotoxic, or cell-destroying, T cells against tumor cells, and represent a new therapeutic approach to cancer therapy. BiTE antibodies have been shown to induce an immunological synapse between a T cell and a tumor cell in the same manner as observed during physiological T cell attacks. These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ultimately inducing a self-destruction process in the tumor cell referred to as apoptosis, or programmed cell death. In the presence of BiTE antibodies, T cells have been demonstrated to serially eliminate tumor cells, which explains the activity of BiTE antibodies at very low concentrations and at very low ratios of T cells to target cells. Through the process of killing cancer cells, T cells proliferate, which leads to an increased number of T cells at the site of attack.

Several antibodies in Micromet’s product pipeline are BiTE antibodies and have been generated based on Micromet’s proprietary BiTE antibody platform. The most clinically advanced BiTE antibody program is MT103 (MEDI-538), targeting CD19, and has provided proof-of-concept in an ongoing phase 1 clinical study in patients with advanced non-Hodgkin’s lymphoma. MT110, which is targeting EpCAM (CD326) and is the first BiTE antibody with potential applications in the treatment of solid tumors, is in a phase 1 clinical trial in patients with lung or gastrointestinal cancers. Three additional BiTE antibodies, targeting CD33, CEA and MCSP, are in preclinical development.

About Blinatumomab

Blinatumomab, also known as MT103 or MEDI-538, is a BiTE(R) antibody being developed with the intent to treat certain types of B cell lymphomas. In February 2006, the U.S. Food and Drug Administration approved an orphan drug designation for blinatumomab for certain types of indolent B cell lymphoma. Blinatumomab also received orphan drug designation from the European Medicines Agency for mantle cell lymphoma and chronic lymphocytic leukemia. Blinatumomab specifically targets the CD19 antigen, which is present on B cells and B cell-derived tumors, but not on other types of blood cells or healthy tissues.

Micromet and MedImmune are developing blinatumomab under the terms of a 2003 agreement in which MedImmune has obtained exclusive rights for blinatumomab in North America. Micromet has retained the rights to blinatumomab outside of North America.

About Micromet, Inc.

Micromet, Inc. (www.micromet-inc.com) is a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases. Four of its antibodies are currently in clinical trials, while the remainder of the product pipeline is in preclinical development. The BiTE(R) antibody blinatumomab, also known as MT103, is in a phase 2 clinical trial for the treatment of patients with acute lymphoblastic leukemia and in a phase 1 clinical trial for the treatment of patients with non-Hodgkin’s lymphoma. BiTE antibodies represent a new class of antibodies that activate the T cells of a patient’s own immune system to eliminate cancer cells. Micromet is developing blinatumomab in collaboration with MedImmune, Inc., a subsidiary of AstraZeneca plc. MT110 is the second BiTE antibody in clinical trials, and is being developed by Micromet in a phase 1 clinical trial for the treatment of patients with lung or gastrointestinal cancer. The third clinical stage antibody is adecatumumab, also known as MT201, a human monoclonal antibody which targets epithelial cell adhesion molecule (EpCAM)-expressing solid tumors. Micromet is developing adecatumumab in collaboration with Merck Serono in a phase 1b clinical trial evaluating adecatumumab in combination with docetaxel for the treatment of patients with metastatic breast cancer. The fourth clinical stage antibody is MT293 which is licensed to TRACON Pharmaceuticals, Inc. and is being developed in a phase 1 clinical trial for the treatment of patients with cancer. Three additional BiTE antibodies, targeting CD33, CEA and MCSP, are in preclinical development. In addition, Micromet has established a collaboration with Nycomed for the development and commercialization of MT203, a human antibody neutralizing the activity of granulocyte/macrophage colony stimulating factor (GM-CSF), which has potential applications in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid arthritis, psoriasis, or multiple sclerosis.

About MedImmune

MedImmune is wholly owned by AstraZeneca plc (LSE: AZN.L, NYSE: AZN) and is the worldwide biologics business for the AstraZeneca Group. The company has approximately 3,000 employees worldwide and is headquartered in Gaithersburg, Maryland. MedImmune strives to provide better medicines to patients, new medical options for physicians and rewarding careers to employees. Dedicated to advancing science and medicine to help people live better lives, the company is focused on infection, oncology, respiratory disease and inflammation, cardiovascular/gastrointestinal disease and neuroscience. For more information, visit MedImmune’s website at www.medimmune.com.

Forward-Looking Statements

This release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different from historical results or from any future results expressed or implied by such forward-looking statements. Factors that may cause actual results to differ materially from any future results expressed or implied by any forward-looking statements include the risk that product candidates that appeared promising in early research, preclinical studies or clinical trials do not demonstrate safety and/or efficacy in subsequent clinical trials, the risk that encouraging results from early research, preclinical studies or clinical trials may not be confirmed upon further analysis of the detailed results of such research, preclinical study or clinical trial, the risk that additional information relating to the safety, efficacy or tolerability of our product candidates may be discovered upon further analysis of preclinical or clinical trial data, the risk that we or our collaborators will not obtain approval to market our product candidates, the risks associated with reliance on outside financing to meet capital requirements, and the risks associated with reliance on collaborators, including MedImmune, Merck Serono, TRACON and Nycomed, for the funding or conduct of further development and commercialization activities relating to our product candidates. You are urged to consider statements that include the words “ongoing”, “may”, “will”, “would”, “could”, “should”, “believes”, “estimates”, “projects”, “potential”, “expects”, “suggests”, “plans”, “anticipates”, “intends”, “continues”, “forecast”, “designed”, “goal”, or the negative of those words or other comparable words to be uncertain and forward-looking. These factors and others are more fully discussed in our periodic reports and other filings with the SEC.

Any forward-looking statements are made pursuant to Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and, as such, speak only as of the date made. Micromet, Inc. undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE Micromet, Inc.

CONTACT:
US Media:
Andrea tenBroek, or Chris Stamm
+1-781-684-0770
micromet@schwartz-pr.com

European Media:
Ludger Wess
+49-40-8816-5964
ludger@akampion.com

US Investors: Susan Noonan
+1-212-966-3650
susan@sanoonan.com

European Investors: Ines-Regina Buth
+49-30-2363-2768
ines@akampion.com